hrp0097p1-564 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

A case of Klinefelter Syndrome and peripheral precocious puberty

Deodati Annalisa , Todisco Tommaso , Ubertini Graziamaria , Bizzarri Carla , Cappa Marco

Background: Klinefelter syndrome (KS) is a genetic disorder consisting in a variable number of additional X chromosomes in a male individual. KS patients can rarely develop peripheral precocious puberty (PPP) caused by extragonadal germ cell cancers (eGCCs) producing hormones with androgenic activity. KS patients are at higher risk for eGCC when compared to the healthy populationCase report: We report the case of M., a 8...